A busy night market aimed at tourists is also located in Patpong.

Patpong (location: 13°43′42″N 100°32′00″E / 13.72833°N 100.5333333°E / 13.72833; 100.5333333Coordinates: 13°43′42″N 100°32′00″E / 13.72833°N 100.5333333°E / 13.72833; 100.5333333) consists of two parallel side streets running between Silom Road and Surawong Road and one side street running from the opposite side of Surawong. Patpong is within walking distance from the BTS Skytrain Silom Line's Sala Daeng Station, and MRT Bangkok Metro Blue Line's Si Lom Station.

Patpong 1 is the main street with many bars of various kinds. Patpong 2 also has many similar bars. Next to these lies Soi Jaruwan, sometimes referred to as Patpong 3 but best known as Silom Soi 4. It has long catered to gay men, whilst nearby Soi Thaniya has expensive bars with Thai hostesses that cater almost exclusively to Japanese men.

Patpong gets its name from the family that owns much of the area's property, the Patpongpanich (or Patpongpanit), immigrants from Hainan Island, China, who purchased the area in 1946. At that time it was an undeveloped plot of land on the outskirts of the city. A small klong (canal) and a teakwood house were the only features. The family built a road - now called Patpong 1 - and several shophouses, which were rented out. Patpong 2 was added later, and both roads are in fact private property and not city streets. (The so-called Patpong 3 and Soi Thaniya are not owned by the Patpongpanich family.) The old teak house was torn down long ago and the klong was filled in to make room for more shophouses. Originally simply an ordinary business area, the coming of the bars eventually would drive out most of the other businesses.

By 1968, a handful of nightclubs existed in the area, and Patpong found some use as a R&R (Rest and Recuperation) location for U.S. troops serving in the Vietnam War, although the main R&R area was actually along New Petchburi Road. In its prime during the 1970s and 1980s, Patpong was the premier nightlife area in Bangkok, and was famous then for its sexually explicit shows. In the mid 1980s the sois hosted an annual Patpong Mardi Gras, which was a weekend street fair that raised considerable money for Thai charities. By late 1980s, however, the Patpongpanich family had begun to rent out small lots in the middle of Patpong 1 for a night market.

Today, the nightlife areas of Nana Plaza and Soi Cowboy provide strong competition for Patpong. However, Patpong is the only one within the official entertainment zones decreed by the Thai government in 2004; this allows local venues to legally stay open until 2am, instead of the 1am legal closing time in other areas. Enforcement of that law was initially strict but has varied over time since.

In recent years, there has been a move away from the traditional sex venues in Patpong. Twilo hip hop bar boasts two live bands every night, and is very popular with both tourists and local Thais. Also, Muzzik Cafe has been completely renovated and is a very popular live music bar playing a mixture of Rock, Hip hop and Pop.

Next to Twilo is Funky Dojo with DJs regularly playing both club and house music. Park Bridge, another high class music venue, has just opened across Patpong 2 and is accessible from either the Foodland car park or the opposite building from the third floor. Radio City and Lucifer are also being refurbished, which will mean by November 2008 Patpong will be one of the main live music areas in Bangkok.

Most Patpong go-go bars feature women dancing on a stage. The dancers (and even occasionally the serving staff) are generally available to customers willing to pay a bar fine to take them out of the bar; the fees for sexual services are negotiated separately. Some establishments advertising "massages" are in fact disguised brothels, and a few famous "blowjob bars" offer oral sex at the main bar or in back rooms.

Several upstairs bars still feature (technically illegal) sex shows, with women performing various creative acts. Perhaps the most notorious of these features women performing exotic feats involving their genitalia and projectile table tennis balls. Some of these second-floor bars are run by scam artists who lure tourists with offers of low prices and later present a wildly inflated bill along with a threat of physical harm should the bill go unpaid. The Tourist Police, usually stationed at Patpong 1 and Silom Road, can help in these situations.